In line with the observations that SLAMF members modulate the function of phagocytes, three SLAMF receptors (SLAMF1, SLAMF2, and SLAMF6) also affect the pathogenesis of murine models of colitis, which are complex, multifaceted immune events, including activation of the mucosal immune system by microbes. Here, SLAMF6 is linked to colitis.