Melatonin has been associated with a decline in VEGF secretion levels in the serum of advanced cancer patients (Lissoni et al., 2001), in addition to markedly reducing the expression of VEGF in HUVEC and culture cancer cells at 1 μM and 1 mM (Dai et al., 2008; Cui et al., 2012; Álvarez-García et al., 2013; Gonçalves et al., 2014). Here, VEGFA is linked to cancer.