More recently, an integrated genomic characterization of ACC, combining exome sequencing, SNP arrays, DNA methylation analysis, mRNA expression arrays, and microRNAs (miRNAs) sequencing provided a comprehensive overview of known drivers genes (CTNNB1, TP53, CDKN2A, RB1, and MEN1) and newly identified altered pathways (ZNRF3, DAXX, TERT, and MED12) in ACC (26). This evidence concerns the gene RB1 and adrenal cortex carcinoma.