Inspection of the selective WT-unique signaling pathways (Figures 10E,F) revealed a strong link of GIT2-associated proteins with energy regulation (“Type II diabetes mellitus signaling,” “Fat digestion and absorption,” “PPAR signaling pathway,” “Maturity Onset Diabetes of Young (MODY) Signaling,” “AMPK Signaling”), cellular development (“Notch signaling”) and degenerative diseases linked to metabolic dysfunctions [“Huntington’s disease,” “Amyotrophic lateral sclerosis signaling” (53, 110)]. Here, GIT2 is linked to neurodegenerative disease.