Therefore, it is perhaps not surprising that the GIT2KO mice do not present such a singular dramatic pathological phenotype as the effects of GIT2 deletion are likely to be highly multidimensional: GIT2 genomic deletion has already been shown to affect central nervous system aging and DNA repair (18), immune function (169), bone mineral density, bone marrow adiposity (170), and anxiety/stress phenotypic behavior (159). Here, GIT2 is linked to Anxiety.