DNA instability has been associated with an advanced rate of aging for several decades (28–30) and this has been reinforced with the appreciation that accelerated molecular aging occurs in patients possessing mutations in multiple DDR proteins including ATM (31), WRN [Werner syndrome, RecQ helicase-like (32, 33)], and BLM [Bloom syndrome, RecQ helicase-like (34)]. This evidence concerns the gene RECQL and Bloom syndrome.