Thabut et al. (2011) also reported that sorafenib was capable of inhibiting the Kruppel-like factor (KLF6)-Angiopoietin-1 (Ang1)-fibronectin molecular triad, thereby suppressing intrahepatic angiogenesis and attenuating liver fibrosis (Thabut et al., 2011). Here, ANGPT1 is linked to Hepatic fibrosis.