APP and Alzheimer disease: The present findings are highly consistent with numerous neuropathological reports describing a degeneration of microvessels in certain brain regions in AD patients (Bell and Ball, 1986; Fischer et al., 1990; Buèe et al., 1997; Bouras et al., 2006) and APP mice (Lee et al., 2005; Kouznetsova et al., 2006).