FOS and epilepsy: There are also studies from other groups using the same standard or modified mouse epilepsy model that showed impaired extinction of fear and maintained amygdala-hippocampal theta synchrony (Lesting et al., 2011); c-Fos, JunD and HSP27 immunoreactivity in different parts of the brain following SE (Dubé et al., 1998); impairs spatial memory (Detour et al., 2005); and depressive impairments (Pineda et al., 2010).