P2RX7 and mood disorder: Thus, a deficient astrocyte-derived ATP release providing an insufficient P2X2 receptor-mediated neuronal tonus was identified in chronically stressed mice (Cao et al., 2013); also, the prevention of excessive P2X7 receptor activation in glial cells ameliorates depressive-like conditions (Stokes et al., 2015) and P2X7 receptor polymorphisms lead to vulnerability to mood disorders (Bennett, 2007).