Although clarifying the precise timing and release of cells to MMP after ischemia requires further study, MMPs, including MMP-9 (gelatinase B), MMP-2 (gelatinase A), and MMP-3 (stromelysin-1), are thought to be key molecules involved in BBB opening and ICB after ischemic stroke (Rosenberg et al., 1995; Castellanos et al., 2003; Wang et al., 2003; Suzuki et al., 2007; Mishiro et al., 2012; Jickling et al., 2014) together with other brain proteases (i.e., plasmin, endogenous t-PA, and urokinase; Wang and Shuaib, 2007). Here, PLG is linked to ischemic stroke.