Although VEGF is induced in ECs through HIF-1α (Tang et al., 2004), and the expression of HIF-1 and HIF-2 are increased in the border area of ischemic stroke (Marti et al., 2000), the mechanisms by which VEGF gene expression is regulated during cerebral ischemia remain unclear. The gene discussed is VEGFA; the disease is Cerebral ischemia.