APLN and in situ carcinoma: To identify peptides which share the common information represented by the frequency component F(0.057), 270 human peptides of the Human Neuropeptide sequence database (Kim et al., 2011) were screened by ISM and peptide apelin 28 (Figure 2C) was found to be among the peptides with the highest amplitudes and Signal/Noise values at the frequency F(0.057) in CIS with MAS1 (Figure 2E).