TNF and Parkinson disease: Although this was observed for IL-5, IL-15, and MIG in SN, and IL-2, TNF-α, IL1-RA, IL-15, and IFN-γ in striatum (Figures 2, 3), a clear increase in the number of PD samples having higher positive values was apparent, confirming the changes in these cytokines in the diseased samples.