Different events in the healing process are triggered by their action and interaction.7–9 Their role in the process of pleurodesis was studied many times.10–12 A research for their differential diagnostic power has exposed the vascular endothelial growth factor (VEGF) being typically higher in malignant pleural effusion.13 We must also take into account and explore the impact of their systemic effects, particularly the role of VEGF in relation to the acute respiratory distress syndrome.14,15. This evidence concerns the gene VEGFA and acute respiratory distress syndrome.