The results of our study on the correlation between uPA and PAI-1 and classic prognostic factors in primary breast cancer are concordant with the results of a meta-analysis of 8377 patients on the prognostic effect of uPA and PAI-1 in primary breast cancer.7 Correlation between uPA and PAI-1 and tumour size, pathological tumour type and hormone receptors and between uPA and axillary lymph node involvement are in line. This evidence concerns the gene PLAU and breast cancer.