Four of the 12 loci, in or nearCOBLL1/GRB14, IGF2BP1, PLA2G6 and CRTC1, havenot been associated with an overall adiposity trait (such as BMI,BF%, obesity risk) before (Fig. 1 and Supplementary Fig. 6). The gene discussed is GRB14; the disease is obesity due to melanocortin 4 receptor deficiency.