PVT1 and B-cell non-Hodgkin lymphoma: In all three pro-B cell lymphomas analysed, copy number variation analysis confirmed amplification of the Igh locus and c-myc (Fig. 7d and Supplementary Fig. 11) and structural variant calling revealed multiple translocations (Fig. 7d, Supplementary Fig. 11 and Supplementary Data 1) among which the most frequent rearrangement fused the Igh locus to a sequence downstream of the c-myc gene encoding for pvt1, a lncRNA (Supplementary Fig. 11b and Supplementary Data 1).