TP53 and B-cell non-Hodgkin lymphoma: Interestingly, spectral karyotyping and DNA-FISH analysis using Igh and c-myc specific probes revealed recurrent translocations between chromosomes 12 and 15 associated with co-amplifications of the Igh locus and the c-myc oncogene in all five B-cell lymphomas (Fig. 7b,c, and Supplementary Table 6), similar to what has been reported in cNHEJ/p53-deficient mice51.