Genetic variants associated with two or more traits, such as rs7138803 on FAIM2 that related to obesity, T2D and myocardial infarction, rs8192673 on PGC-1α and rs1801282 on PPAR-γ associated with waist circumference and T2D, were revealed by previous studies [32–34]. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.