Similar to the alterations in allogeneic transplant models, The iNOS expression in the splenic CD11b+ Ly6Chigh M-MDSCs of alloskin-grafted or tumor-bearing Lyzs-mTOR KO recipients were significantly decreased than WT recipients as detected by flow cytometry (P < 0.001, Fig. 5D). The gene discussed is MTOR; the disease is neoplasm.