Both resveratrol and polydatin have the effects of anti-inflammation, anti-oxidation, cytoprotection in stress conditions, anti-hyperlipidemia, anti-hyperglycemia and many other cardiovascular protection merits [29, 32, 37–40], mainly through the signal pathways such as IKKs/NF-κB, Nrf2/ARE, Akt, AMPK, AMPK -Kir6.2/K-ATP [25, 32, 40–42]. The gene discussed is NFKB1; the disease is Hyperglycemia.