Given that P. aeruginosa infection in syndecan-1 deficiency results in attenuated pro-inflammatory cytokine responses [31], it is plausible that increased susceptibility to this pathogen would also be observed in the Sdc1-/- mice with the subacute PD model during the first 4 h of infection where pro-inflammatory cytokines orchestrate the innate immune response to pathogen invasion. The gene discussed is SDC1; the disease is infection.