Although syndecan-1 was shown to be involved in angiogenesis, in that Sdc1-/- mice exhibited increased corneal neovascularization in an angiogenesis assay [28] and syndecan-1 overexpression promoted tumor angiogenesis [12], we found that the increased vessel density in dialyzed animals was similar between Sdc1-/- and wild type mice. This evidence concerns the gene SDC1 and neoplasm.