For the third criterion, it has already been demonstrated that cells with CA proliferate more slowly [24, 52], which would tend to cause lower grade tumors; however, numerical CA positively correlates with Ki67 status in our data set (Pearson r = 0.3106, p < 0.001, Fig. 1d) suggesting that CA does not cause tumor cells to exit the cell cycle. Here, MKI67 is linked to neoplasm.