NPM1 and acute myeloid leukemia: Patients with low ITD allele burden and NPM1 mutation were reported to show a similar prognostic impact to FLT3 wild-type AML, whereas those with low ITD and wild-type NPM1 had a higher risk of relapse and shortened OS than FLT3 wild-type patients.26 To investigate the potential effect of low allele burden and short length of FLT3-ITD, we evaluated the prognostic impact of FLT3-ITD in restricted to CN-AML.