GPT and encephalitis: Eight (40.0 %) patients had severe organ involvement, including 5 (62.5 %) patients with an AST level >1,000 U/L and/or an ALT level >1,000 U/L, 4 (50.0 %) patients with a serum creatinine level ≥3 times above the baseline, 2 (25.0 %) patients with myocarditis, and 1 (12.5 %) patient with encephalitis (Fig. 1).