Recently, multiple lines of genetic evidence have highlighted roles for RGS family proteins in mediating autoimmune disease: (1) The International Multiple Sclerosis Genetics Consortium (IMSGC) identified RGS1 as a novel MS susceptibility locus [16]; (2) SNPs of RGS1, RGS7, RGS9, and RGS14 are highly correlated with a diagnosis of MS, Crohn’s disease (CD), and ulcerative colitis (UC) [16–20]; (3) The mRNA levels of RGS10 are higher in the peripheral blood mononuclear cells (PBMC) from patients with MS, CD, and UC compared to those in unaffected individuals [21]. Here, RGS14 is linked to myeloid sarcoma.