TYMS and neoplasm: We speculate therefore that somewhat better survival of patients with tumors exhibiting E2F1+TS- immunophenotype, as compared to the worst survival associated with E2F1+TS+ immunophenotype, may reflect dual activity of E2F1 and point to the important role of increased TS expression which when induced by E2F1 may promote proliferation of tumor cells and resistance to 5FU-based treatment.