However, through the research in rs12914385 and rs8042374 neither rs938682 nor rs578776, Wang, et al. emphasized that CHRNA3 might impact indirectly on lung cancer rather than direct effect mainly due to two arguments listed below: variants carriers in CHRNA3 SNPs increase CPD (cigarettes per day); for never smokers the association between SNPs and lung cancer susceptibility may not be significant42. The gene discussed is CHRNA3; the disease is lung carcinoma.