From then on, numerous studies have suggested CHRNA3 gene polymorphisms are associated with many types of cancers detection and treatment including lung cancer, gastric cancer, esophageal cancer9, 10, 11, etc. Other meta-analysis indicated rs105173012, rs649530913, rs12914385, rs804237414 in CHRNA3 were associated with lung cancer risk and part of them even had racial difference. The gene discussed is CHRNA3; the disease is cancer.