MFAP5 and amyotrophic lateral sclerosis: Furthermore we see a downregulation for the ECM transcripts tenascin C (Tnc) and microfibrillar associated protein 5 (Mfap5)27, 28 as well as a strong upregulation for collagen type XIXα1 (Col19a1), which has also been found to be upregulated in ALS muscle29.