PTPRO and diabetes mellitus: The previously identified UMOD locus showed genome-wide significant association with eGFRcrea among those with diabetes (Supplementary Fig. 2; rs12917707, P value=2.5 × 10−8), and six loci (NFKB1, UNCX, TSPAN9, AP5B1, SIPA1L3 and PTPRO) had nominally significant associations with eGFRcrea among those with diabetes.