CST3 and chronic kidney disease: We analysed associations of eGFR based on serum creatinine (eGFRcrea), cystatin C (eGFRcys, an additional, complementary biomarker of renal function) and CKD (defined as eGFRcrea <60 ml min−1 per 1.73 m2) with ∼2.5 million autosomal single-nucleotide polymorphisms (SNPs) in up to 133,413 individuals of European ancestry from 49 predominantly population-based studies (Supplementary Table 1).