In fact, one of the RNAs showing the highest dysregulation in females during relapse (fold change of 9.21) is ACA40, which is one of the transcripts also showing the mirror pattern. Moreover, this snoRNA has been described to have a central role in the regulation of gene expression in MS according to co-expression networks and it has been suggested as a potential therapeutic target in MS48. This evidence concerns the gene SNORA40 and myeloid sarcoma.