Patients with intracranial aneurysms had a significantly higher frequency of APOE E2/E2 genotype (OR = 9.51, 95 % CI = 1.19, 76.04; P = 0.03) and APOE E2/E3 genotype (OR = 1.87, 95 % CI = 1.03, 3.40; P = 0.04) than healthy controls (Table 2). Here, APOE is linked to Dilatation of the cerebral artery.