PIK3C2A and eosinophilic pneumonia: In another study, severe side effects (one case of acute renal failure due to massive rhabdomyolysis, one of eosinophilic pneumonia and 2 cases of asymptomatic transient CPK level elevation) were also reported with daptomycin at a dose of 6.6 mg/kg/day for an average of 44.9 days in the treatment of PJI [13].