CDH2 and colorectal carcinoma: Next, to investigate the function of GrB in CRC cell invasion, we first characterized CRC cell lines for both their expression of three EMT biomarkers (i.e., Snail 1 transcription factor and E- and N-cadherin adhesion molecules) by WB (Fig. 1a, upper panel) and their invasive capability by the invasion assay (Fig. 1c).