The most representative TF genes (FOXA1, FOXD1, NF-kappaB, and KLF4 for SB and ARNT, ELF5, RXRA::VDR, and SOX9 for NT), according to the biological processes in which they are involved and to data in the literature, (e.g. TF involved with kidney diseases and diabetes for SB and TF related to mammary gland tissue and vertebrae composition and spinal cord expression for NT) were chosen to achieve a gene-TF network (Figs. 2, 3). Here, KLF4 is linked to diabetes mellitus.