Insulin resistance (IR) is a state in which physiologic concentrations of insulin produce a subnormal biologic response.1 IR is directly related to the risk of developing metabolism-related disorders, including type 2 diabetes mellitus (T2DM), cardiovascular disease, and even cancer.2 China has experienced an epidemic of major chronic diseases, such as stroke, coronary heart disease, cancer, diabetes, and hypertension, in recent decades. This evidence concerns the gene INS and diabetes mellitus.