Meanwhile, more cleaved caspase-3-positive cells and fewer cells Ki67-positive and p-Stat3-positive cells were observed in the tumor tissues treated with nifuroxazide than in the control group, indicating that nifuroxazide could inhibit cell proliferation and induce cell apoptosis through decreased the expression of p-Stat3 in vivo. The gene discussed is STAT3; the disease is neoplasm.