The established autoantibodies varied in frequency from 4–92% in the APS1 cohort (cutoff = average of the healthy subjects + 3SD), IFNW1 autoantibodies being the most frequently detected autoantibody, and were overall detected in the same range of frequency as previously reported23 (see Supplementary Table S1). The gene discussed is IFNW1; the disease is autoimmune polyendocrine syndrome type 1.