When subjects with HAND were sorted according to the severity of impairment, all three mRNAs were significantly lower in patients diagnosed with HIV-associated dementia (HAD) and Mild Neurocognitive Disorder (MND) compared to seronegative controls (by 24 and 18 % for GAD1, 32 and 22 % for GAD2, 29 and 22 % for GJD2; Fig. S1 d–f). This evidence concerns the gene GAD1 and dementia.