Given the suggested role of calcium signaling in neurodegeneration (Marambaud et al., 2009) and CAMK2 implicationin Alzheimer’s disease (AD) (Steiner et al.,1990), we also analyzed RNA-seq data from three control brains and comparedthem to three AD brains (Bai et al., 2013).Strikingly, in CAMK2D we observe a marked decrease of ~38% of theneuronal specific isoform of the complex, developmentally-regulated mouse LSV wevalidated above, with reciprocal increase in the all exclusion, isoform C in ADbrains (Figure 7C). This evidence concerns the gene CAMK2B and early-onset autosomal dominant Alzheimer disease.