Individuals harboring the S836S/3’UTR haplotype (GTCAC) had higher serum calcitonin level (1860(1160–7087) vs 579(120–2014) pg/mL, P = 0.014), CEA level (584(145–4353) vs 26(7–113) ng/mL, P = 0.007) and larger tumor size (3.3(1.8–4.0) vs 2.1(1.4–3.0), P = 0.062). The gene discussed is CALCA; the disease is neoplasm.