In liver, nearly all transcripts whose expression is modulated by Mgst3 are involved in some aspect of metabolism or detoxification (Acadm, Cyp2b, Dtd1, Vrt), with the notable exception of Sdcbp which is a signaling molecule implicated in tumor growth and metastasis for melanoma [134], hepatoma [135], lung cancer [136], glioma [137], urothelial cell carcinoma [138], and breast cancer [139]. This evidence concerns the gene CYP2B6 and hepatocellular carcinoma.