Whereas reports on the above relationship between peripheral GLP-1 and leptin are relatively new, evidence of a relationship between central GLP-1 and leptin dates back to 1997, when Goldstone and colleagues reported the presence of leptin receptors on mouse hindbrain proglucagon gene (GCG) expressing neurons, as well as the blockade of intracerebroventricular-leptin-induced anorexia in rats by intracerebroventricular exendin 9 (18). This evidence concerns the gene GLP1R and Anorexia.