Similarly, Zhao et al. (41) reported that proinflammatory cytokines including IL-6 decreased significantly in a prospective, single-blind, randomized, placebo controlled group including 76 patients of heart failure assigned to two groups; 38 as experimental group (2 g/day: EPA=0.18 g, and DHA=0.12 g), and 38 as placebo group for 3 months. This evidence concerns the gene IL6 and heart failure.