As shown in Fig 1A and 1B, the phosphorylation of NF-κB p65 and c-Jun/AP-1 was markely elevated in the peritoneal macrophages from BALB/c mice after anti-β2GPI or IgG-APS treatment, compared to control mice injected with NR-IgG. Here, JUN is linked to autoimmune polyendocrinopathy.