The prevalence of low Apgar score and ophthalmic malformations was significantly greater in the patients with cholestasis than in those without: 3/5 (60%) vs 1/11 (9%), p = 0.03 and 5/5 (100%) vs 4/11 (36%), p = 0.02 (Table 3). Interestingly, while no statistically significant difference between the two groups for plasma GH peak, IGF-1 or FT4 levels could be found, the plasma cortisol level was profoundly decreased in patients with cholestasis: 12.4 ng/mL (8–15 ng/mL) vs 79.4 ng/mL (10–210 ng/mL), p = 0.04. This evidence concerns the gene IGF1 and cholestasis.