To test whether the rotavirus infection was able to induce cytopathic effects on tumor cells Sp2/0-Ag14, U937and REH, these cells were separately infected with rotavirus isolates WT1-5, TRUY, WWM, WTEW or ECwt at a MOI of 0.8 as determined in the respective tumor cell. This evidence concerns the gene WT1 and Rotavirus infection.