AKT1 and esophageal squamous cell carcinoma: However, the combined analysis with only three AKT1 SNPs found that having one AKT1 variant genotype was associated with a protective effect (adjusted OR = 0.60, 95% CI = 0.42–0.87, P = 0.007, statistical power = 0.353) for developing ESCC, which is likely because of a chance.