Among all the tested SNPs, we found that AKT1 rs2294750 might exert a protective effect on ESCC risk; in particular, this effect was significant for women (adjusted OR = 0.63, 95% CI = 0.43–0.94, P = 0.024, statistical power = 0.925) and non‐drinkers (OR = 0.79, 95% CI = 0.64–0.99, P = 0.042, statistical power = 0.995) under the dominant model (Table 3A). The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.