TNKS and obesity due to melanocortin 4 receptor deficiency: However, the variants we detected were too infrequent for meaningful obesity association analysis (SDCCAG8 [Thr398Met], TNKS [Pro275Ala], MSRA [Arg6GlufsX88], [Asp142Tyr], [Gly187Ser]) or showed no obesity association (SDCCAG8 [Glu378Asp], TNKS [Gly237Ala]; MSRA [Thr88Met],).