We therefore investigated six (rs2515602, rs2275542, rs2230806, rs1800976, rs4149313, rs3890182) single nucleotide polymorphisms (SNPs) in the ABCA1 gene in a sample consisting of 411 (low HDL-C: 204 and normal control: 207) Kazakh individuals to detect the risk of the interaction ABCA1 gene polymorphisms-obesity and ABCA1 gene variants in low HDL-C disease. The gene discussed is ABCA1; the disease is obesity due to melanocortin 4 receptor deficiency.