AQP5 and Sjogren syndrome: However, abnormal localization of AQP5 has been detected in several animal models for Sjögren’s syndrome including non-obese diabetic (NOD) mice [80,81,82], IQI/JIC mice [82], specific T-cell class IA phosphoinositide 3-kinase (r1∆T/r2n) knockout mice [82], mice immunized with submandibular gland autoantigen [83], and NOD/SCID.E2f1−/− mice [84].