QHF, a herbal component formula composed of cinobufotalin, Panax notoginseng saponins, ginsenosides Rg3 and lentinan, inhibits VEGF, EGFR and MMP-2 expression, as well as angiogenesis and tumor growth in H22 HCC [153] (Table 3). The gene discussed is VEGFA; the disease is neoplasm.