Radix Glycyrrhizae (Gan-Cao) polysaccharide down-regulates Tregs, related cytokines IL-10 and TGF-β, and Foxp3 expression, and increases IL-2 and IL-12p70 level in serum in H22 HCC-bearing mice [147] (Figure 1, Table 3). Here, IL2 is linked to hepatocellular carcinoma.