Tanshinone IIA, isolated from S. miltiorrhiza Bunge (Dan-Shen), inhibits proliferation and induces G2/M cell cycle arrest accompanied by up-regulation of calreticulin, caspase-12 and GADD15, and down-regulation of Bcl-2, Cdc25c and Cdc2 in HCC cells [118]. This evidence concerns the gene BCL2 and hepatocellular carcinoma.