TGFB1 and hepatocellular carcinoma: Compound Astragalus and Salvia miltiorrhiza extract (CASE), a herbal component formula comprising astragalosides, astragalus polysaccharide and salvianolic acids, inhibits TGF-β1 mediated invasion in hepatoma HepG2 cells by modulating TGF-β/Smad signaling [109] (Table 2).