MAPK3 and hepatocellular carcinoma: Artemisinin, from A. annua L. (Qing-Hao), inhibits HCC metastasis by down-regulation of MMP2 and phosphorylation of p38 and ERK1/2, and up-regulation of TIMP2, Cdc42 and E-cadherin [102] (Figure 1, Table 2).