At the time this manuscript was being written, Marti et al. (47) demonstrated that YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma cells; our work complements and extends their data by identifying an Mcl-1-regulated prosurvival pathway, YAP coactivation of TBX5 in addition to TEADs, and the role of FGF5-FGFR2 in Hippo oncogenic signaling of CCA cells. This evidence concerns the gene FGF5 and cholangiocarcinoma.